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Administration Basic Sciences Clinical Sciences Centers of Excellence

 

James  M.  Hill , Ph.D.

Professor of Ophthalmology, Pharmacology, Microbiology and Neuroscience
Director of Pharmacology and Infectious Disease
RPB Senior Scientific Investigator

LSU Eye Center
533 Bolivar Street, Room 3D13 (399)
New Orleans, LA 70112
Phone (office): (504) 568-2274
Phone (Lab): (504) 568-2647, Main Lab
Fax: (504) 568-2385
Email: jhill@lsuhsc.edu

Virology and Pharmacology Laboratory

CV

Degrees

B.S., Zoology
Spring Hill College
Mobile, AL
1964

M.S., Microbiology
University of Mississippi
School of Medicine
Jackson, MS
1967

Ph.D., Pharmacology
Baylor College of Medicine
Houston, TX
1971

Fellowship in Molecular Biology
& Biochemistry
Harvard Medical School
Massachusetts General Hospital
Boston, MA
1971-73

Research Interests Pathogenesis and chemotherapy of viral and bacterial keratitis; unique drug delivery systems
Selected Publications

As of May 16, 2013, Dr. Hill has 4,893 cumulative citations based on Science Citation Index. These include 32 publications with greater than 50 citations; 14 with 100 citations or more; 7 with 150 citations; and 4 with greater than 250 citations.

Rolfsen ML, Frisard, NE, Stern EM, Foster TP, Bhattacharjee PS, McFerrin HE, Clement C, Rodriguez PC, Lukiw WJ, Bergsma DR, Ochoa AC, Hill JM.  Corneal Neovascularization:  A Review of the Molecular Biology and Current Therapies. Expert Review of Ophthalmology. 8(2)167-189, 2013.

Alexandrov PN, Dua P, Hill JM, Bhattacharjee S, Zhao Y, Lukiw WJ.  microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF). Int J Biochem Mol Biol.  2012;3(4):365-73, 2012.  PMID: 23301201

Bhattacharjee PS, Huq TS, Potter V, Young A, Davenport IR, Graves R, Mandal TK, Clement C, McFerrin HE, Muniruzzaman S, Ireland SK, Hill JM.  High-glucose-induced enothelial cell injury is inhibited by a peptide derived from human apolipoprotein E.  PLOS ONE.  2012.  PMID: 23284911

Li S, Lee J, Zhou Y, Gordon WC, Hill JM, Bazan NG, Miner JH, Jin M.  Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase.  J Neurosci.  In Press, 2012.

Hill JM, Nolan NM, McFerrin HE, Clement C, Foster TP, Halford WP, Kousoulas KG, Lukiw WJ, Thompson, HW, Stern EM, Bhattacharjee PS.  HSV-1 latent rabbits shed viral DNA into their saliva.  Virology J 9(1):221, 2012 PMID: 23021094

Ball MJ, Lukiw WJ, Kammerman E, Hill JM.  Intracerebral propagation of Alzheimer's disease confirms its herpes virus etiology.  Alzheimer's & Dementia.  2012. PMID: 23159044

Webre JM, Hill JM, Clement C, Nolan NM, McFerrin HE, Bhattacharjee PS, Hsia V, Neumann DM, Foster TP, Lukiw WJ, Thompson HW. Rabbit and mouse models of HSV-1 latency, reactivation and recurrent eye diseases. J Biomed Biotech 2012:612316,2012.  PMID: 23091352

Lukiw WJ, Dua P, Pogue AI, Eicken C, Hill JM. Up-regulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler Scheinker (GS) syndrome. J Toxicol Env Health 74:1460-1468, 2011. PMID:22043907

Pogue AI, Dua P, Eicken C, Hill JM, Lukiw WJ. Up-regulation of NF-kB sensitive miRNA-125b and miRNA 146a in a metal sulfate-stressed human astroglial (HAG) primary cell culture. J Inorganic Biochem 105:1434-1437, 2011. PMID: 22099153

Al-Dujaili LJ, Clerkin PP, Clement C, McFerrin HE, Bhattacharjee PS, Varnell ED, Kaufman HE, Hill JM. Ocular HSV: How are latency, reactivation and therapy interrelated? Future Microbiol 6:877-907, 2011. PMID: 21861620

Li YY, Ciu JG, Hill JM, Bhattacharjee S, Zhao Y, Lukiw WJ. Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models. Neurosci Lett 487:94-98, 2011. PMID: 20934487

Bhattacharjee PS, Huq TS, Mandal TK, Graves RA, Muniruzzaman S, Clement C, McFerrin HE Jr, Hill JM. A novel peptide derived from human apolipoprotein E is an exhibitor of tunor growth and ocular angiogenesis. PLoS ONE  Jan 2011;6:e15905. PMID: 21099411

Clement C, Capriotti JA, Kumar M, Hobden J, Foster TP, Bhattacharjee PS, Thompson HW, Mahmud R, Liang B, Hill JM. Clinical and antiviral efficacy of an ophthalmic formation of dexamethasone providone-iodine in a rabbit model of adenoviral keratoconjunctitivis. Invest Ophthalmol Vis Sci 52:339-344, 2011.  PMID: 20702820

Bedadala G, Palem J, Graham L, Hill J, McFerrin H, Hsia S. Lytic HSV-1 infection induces the multifunctional transcription factor Early Growth Response-1 (ERG-1) in rabbit corneal cells. Virology J 8:262, 2011. PMID:21619646

Clement C, Bhattacharjee PS, Kumar M, Foster TP, Thompson HW, Hill JM. Upregulation of mouse genes in HSV-1 latent TG after butyrate treratment implicates the multiple roles of the LAT-ICP0 locus. Invest Ophthalmol Vis Sci 52:1770-1779, 2011. PMID:20881297

 Hobden JA, Kumar M, Kaufman HE, Clement C, Varnell ED, Bhattacharjee PS, Hill JM. In vitro synergism of trifluorothymidine and ganciclovir against HSV-1. Invest Ophthalmol Vis Sci 52:830-833, 2011. PMID:20861476

Kennedy DP, Clement C, Arceneaux RL, Bhattacharjee PS, Huq TS,Hill JM. Ocular HSV-1: Is the cornea a reservoir for viral latency or a fast pit stop? Cornea 30:251-259, 2011. PMID:21304287

Lukiw WJ, Cui JG, Yuan LY, Bhattacharjee PS, Corkern M, Clement C, Kammerman EM, Ball MJ, Zhao Y, Sullivan PM, Hill JM. Acyclovir or AB42 peptide attenuate HSV-1- induced miRNA-146a levels in human brain cells. NeuroReport 21:922-927, 2010. PMID: 20683212

Hsia S-C, Pinnoji RC, Bedadala GR, Hill JM, Palem JR. Regulation of HSV-1 thymine kinase expression by thyroid hormone receptor in cultured neuronal cells. J NeuroVirol16:13-24,2010. PMID: 20113192

Shah SS, Denham VL, Elison JR, Bhattacharjee PS, Clement C, Huq T, Hill JM. Drug delivery to the posterior segment of the eye for pharmacologic therapy. Expert Rev Ophthalmol 5:75-93, 2010.  PMID: 20305803

 Kumar M, Kaufman HE, Clement C, Bhattacharjee PS, Huq T, Varnell ED, Thompson HW, Hill JM. Effect of high versus low oral doses of valacyclovir on herpes simplex virus-1 DNA sheddig into tears of latently infected rabbits. Invest Ophthalmol Vis Sci 2010 April 14 [Epub ahead of print] PMID: 20393107

Cohrs RJ, Koelle DM, Schuette MC, Mehta S, Pierson D, Gilden DH, Hill JM. Asymptomatic alphaherpesvirus reactivation. In: Gluckman TR (ed). Herpesviridae: Viral Structure, Life Cycle and Infections. Hauppauge, NY: Nova Publishers, chapter. 6: 133-168, 2009.

Hill JM , Denham LV, Booth BA, Friedman DA, Hobden JA, Murina AT, Acierno MD, Jacob JT, Kaufman HE, Bergsma DR. Chapter 20: Ocular pharmacology. In: Agarwal AS (ed). Color Atlas of Ophthalmology. 2nd ed. Jaypee Brothers Medical Publishers, India, 2009, pp 405-429.

Hill JM , Clement C. HSV-1 DNA in human corneas: What are the virological and clinical implications? J Inf Dis 200:1-4, 2009. PMID: 19476431

Kumar M, Hill JM, Clement C, Varnell ED, Thompson HW, Kaufman HE. A double-blind placebo-controlled study to evaluate valacyclovir alone and with aspirin for asymptomatic HSV-1 DNA shedding in human tears and saliva. Invest Ophthalmol Vis Sci, 50: 5601-5608, 2009. PMID: 19608530 

 Hill JM, Zhao Y, Clement C, Neumann D, Lukiw W. HSV-1 infections of human brain cells induce miRNA-146a and Alzheimer-type inflammatory signaling. NeuroReport 20:1500-1505, 2009.PMID: 19801956

Clement C, Bhattacharjee PS, Kaufman HE, Hill JM. Heat-induced reactivation of HSV-1 in latently infected mice: Upregulation in the trigeminal ganglia of predominantly CD83 and other immune response genes and their potential role in the viral LAT-ICPO locus. Invest Ophthalmol Vis Sci 50:2855-61, 2009. PMID: 19151393

Bhattacharjee PS, Neumann DM, Hill JM. A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits. Curr Eye Res 34:99-102, 2009. PMID: 19219680

Bhattacharjee PS, Neumann DM, Foster TP, Clement C, Singh G, Thompson HW, Kaufman HE, Hill JM. Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model. Invest Ophthalmol Vis Sci, 49(10)4263-8, 2008. PMID: 18515564

Hill JM, Ball MJ, Neumann DM, Azcuy AM, Bhattacharjee PS, Bouhanik S, Clement C, Lukiw WJ, Foster TP, Kumar M, Kaufman HE, Thompson TW. The high prevalence of HSV-1 DNA in human trigeminal ganglia is not a function of age or gender. J Virol, 82(16):8230-34, 2008. http://jvi.asm.org/cgi/reprint/JVI.00686-08v1?view=long&pmid=18550674

Bhattacharjee PS, Neumann DM, Foster TP, Bouhanik S, Clement C, Vinay D, Thompson HW, Hill JM: Effect of human apolipoprotein E genotype on the pathogenesis of experimental ocular HSV-1. Exp Eye Res, 87:122-30, 2008.  http://www.ncbi.nlm.nih.gov/pubmed/18572164?dopt=Citation

Giordani NV, Neumann DM, Bhattacharjee PS, McAnany PK, Hill JM, Bloom DC. During HSV-1 latency in rabbits, an inability to express LAT corresponds to an increased repression of lytic genes: J Virol, 82(12):6056-60, 2008. http://jvi.asm.org/cgi/content/full/82/12/6056?view=long&pmid=18400860

Clement C, Popp MP, Bloom D, Schultz G, Liu L, Neumann DM, Bhattacharjee PS, Hill JM. Microarray analysis of host gene expression for comparison between naïve and HSV-1 latent rabbit TG. Mol Vis, 14:1208-1220, 2008. http://www.molvis.org/molvis/v14/a142

Toma HS, Murina AT, Areaux RG, Neumann DM, Bhattacharjee PS, Foster TP, Kaufman HE, Hill JM:  Ocular HSV-1 latency, reactivation and recurrent disease. Sem Ophthalmol, 23(4):249-73, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18584563?dopt=Citation

Neumann DM, Bhattacharjee PS, Giordani NV, Bloom DC, Hill JM. In vivo changes in the patterns of chromatin structure associated with the latent herpes simplex virus type 1 genome in mouse trigeminal ganglia can be detected at early times after butyrate treatment. J Virol 81:13248-13253, 2007. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17881451

Neumann, DM, Bhattacharjee PS, Hill, JM. Sodium butyrate: A chemical inducer of in vivo reactivation of HSV-1 in the ocular mouse model. J Virol 81:6106-6110, 2007.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17360760

Cui JG, Hill JM, Zhao Y, Lukiw WJ: Expression of inflammatory genes in the primary visual cortex of late-stage Alzheimer’s disease. NeuroReport. 18: 115-119, 2007.

Friedman DA, Lukiw WJ, Hill JM: Apolipoprotein E ε4 offers protection against age-related macular degeneration, Med Hypotheses 68: 1047-1055, 2007.  PM:17141963

Hill JM , Bhattacharjee PS, Neumann DM: Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal disease. Exp Eye Res 84:801-811, 2007. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17007837

Booth BA, Denham LV, Bouhanik S, Jacob JT, Hill JM.  Sustained release ophthalmic drug delivery systems for treatment of macular disorders:  Present and future applications.  Drug Aging 24:581-602, 2007.  PM:17658909

Pinnoji RC, Bedadala GR, George B, Holland TC, Hill JM, Hsia SV: Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification. Virol J 4:56, 2007.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17555596

Myles ME, Neumann DM, Hill JM: Recent progress in ocular drug delivery for posterior segment disease: emphasis on iontophoresis. Adv Drug Deliver Rev 57:2063-2079, 2006. PM:15254144

Kammerman, EM, Neumann DM, Ball MJ, Lukiw W, Hill, JM: Senile plaques in Alzheimer’s diseased brain: possible association of beta-amyloid with HSV-1 L-particles. Med Hypotheses, 66: 294-299,2006. PM:16242250

Bhattacharjee PS,Neumann DM,Stark D, Thompson HW, Hill JM: Apolipoprotein E modulates establishment of HSV-1 latency and survival in a mouse ocular model. Curr Eye Res, 31:703-708, 2006. PM:16966142

Hill JM , Gebhardt BM, Azcuy AM, Matthews KE, Lukiw WJ, Steiner I, Thompson HW, Ball MJ: Can a herpes simplex virus type 1 neuroinvasive score be correlated to other risk factors in Alzheimer’s disease? Med Hypotheses 64:320-327, 2005.  PM:15607565

Danaher RJ, Jacob RJ, Steiner MR, Allen WR, Hill JM, Miller CS: Histone deacetylation inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript (LAT)-independent manner in neuronal cells. J Neurovirology 11:306-317, 2005. PM:16036811